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RT-QuIC Substrate

Molecular Research Use Only
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QuIC Kits

QuIC Kits

$426.00 USD
$426.00 USD
Shipping calculated at checkout

Ideal for detection of prion-related diseases such as Chronic Wasting Disease and Creutzfeldt-Jakob Disease. Utilizes Priogen's MNPROtein substrate--truncated recombinant prion protein (Syrian hamster, aa 90–231) optimized for QuIC assays. Molecular research purposes only.

Bulk orders greater than 100 plates available with a potential 2 month lead time. All orders come with free shipping. Shipped on dry ice via FedEx on Mondays, Tuesdays, and Wednesdays excluding holidays.


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Every Batch Validated With Controls
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QuIC Kits

$426.00 USD
$426.00 USD
QuIC Kits
QuIC Kits

Kits and Reagents: 2 RT-QuIC Kit sampler (free shipping)

QuIC Kits

Priogen's QuIC Kits and Reagents:

RT-QuIC

  • Ultra-sensitive kit for the detection of multiple prion disorders
  • Use for biological and ecological samples
  • Each kit provides reagents for 1 96-well plate or 1/2 384-well plate
  • Ready to use, no filtering

Nano-QuIC™

  • Improves RT-QuIC reaction kinetics (speed, sensitivity)
  • Use for blood, brain, and lymph node samples
  • Each kit provides reagents for 1 96-well plate or 1/2 384-well plate
  • Ready to use, no filtering

10x Dilution Buffer

  • For use with Priogen's Nano-QuIC™ and RT-QuIC kits
  • 1% SDS, 10x PBS (1.1 mL)
  • Ready to use, no filtering

We are the QuIC experts

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High-throughput RT-QuIC

Priogen's founding team pioneered high-throughput QuIC testing. The team operates one of the largest RT-QuIC labs in the world, running thousands of reactions every week.

Powered by MNPROtein™ Substrate

Used in a growing number of peer-reviewed research studies, our QuIC kits leverage the industry standard RT-QuIC recombinant substrate, MNPROtein™. MNPROtein™ is used in academic, government, and industry research labs around the world, allowing for direct comparison of results (see below for more information).

Nano-QuIC™ Technology

Nano-QuIC™ improves RT-QuIC reaction kinetics for tissue samples by orders of magnitude. The assay overcomes inhibitors present in blood and brain samples, facilitating the testing of a greater range of dilutions.

Improve RT-QuIC performance with Nano-QuIC™

Priogen's Nano-QuIC™ technology improves RT-QuIC reaction kinetics and overcomes inhibitors associated with various sample types. By incorporating silica nanoparticles into the RT-QuIC assay, Nano-QuIC™ reduces detection times (top graph) and boosts sensitivity helping to reduce false-negative results (bottom graph). Read more about Nano-QuIC™ in our published manuscript.

MNPROtein™ Substrate

Click here to learn more about our MNPROtein™ QuIC Substrate

Priogen's QuIC kits ship with MNPROtein™, a Syrian hamster recombinant truncated prion protein (amino acids 90–231) optimized for QuIC experiments. Recognizing the need for RT-QuIC standardization, our founding team began mass-producing MNPROtein™ at the University of Minnesota in 2019. An increasing number of peer-reviewed publications use MNPROtein™, allowing for cross-lab comparison of results and replication of published findings.

Concentration of MNPROtein™ is determined with A280, mass attenuation coefficient of 1.4, and is purified with nickel-affinity chromatography. Every batch of MNPROtein™ is produced with high quality control through current Good Manufacturing Practice aligning with FDA CFR Title 21 Part 211, and is internally validated for performance before shipping as part of RT-QuIC and Nano-QuIC™ kits.

Click here for peer-reviewed manuscripts using MNPROtein™