CWD Test Kits

Venison testing
RT-QuIC Substrate

Molecular Research Use Only
Research Services

Academic, State, Tribal, Federal
chevron_left chevron_right
MNPROtein™ - RT-QuIC Substrate
MNPROtein™ - RT-QuIC Substrate
MNPROtein™ - RT-QuIC Substrate
chevron_left
chevron_right

MNPROtein™ - RT-QuIC Substrate

Truncated recombinant prion protein (Syrian hamster, aa 90–231) optimized for RT-QuIC assays. Each batch is purified via nickel-affinity chromatography, quantified by a Bradford assay, and quality-audited externally. Internal validation includes RT-QuIC with positive and negative controls to ensure consistent performance. Originally developed at the University of Minnesota by Priogen's founding team. 

Applications: Ideal for RT-QuIC detection of prion-related diseases such as Chronic Wasting Disease and Creutzfeldt-Jakob Disease. Molecular research purposes only.

Pricing: $154.43 per 96-well plate. Bulk orders greater than 100 plates available with a potential 2 month lead time. All orders come with free shipping. Shipped on dry ice via FedEx on Mondays, Tuesdays, and Wednesdays excluding holidays.

International or PO orders, email us at sales@priogen.bio or call 612-200-2643 (ext 2). 

Every Batch Validated With Controls
Highly Competitive Price
Exceptional Quality & Performance
Quantity

In Stock

Sold out

Unavailable

MNPROtein™ - RT-QuIC Substrate

$325.00 USD
$165.00 USD $325.00 USD
MNPROtein™ - RT-QuIC Substrate
MNPROtein™ - RT-QuIC Substrate

Quantities : 2 96-well plate sampler (free shipping)

MNPROtein™ - RT-QuIC Substrate
MNPROtein™ - RT-QuIC Substrate
MNPROtein™ - RT-QuIC Substrate

The First Commercially Available RT-QuIC Substrate

Why MNPROtein™?

  • Perfect for high-throughput RT-QuIC testing. Ready to use, no filtering
  • Multi-lab validated, more peer-reviewed publications than any other commercially available RT-QuIC substrate
  • Over 50% cheaper than alternative options
  • Priogen is the only RT-QuIC substrate provider who performs the assay daily, allowing for real-time quality assurance
  • Developed and commercialized at the University of Minnesota by Priogen's founding team in 2022

Peer-Reviewed Publications Using MNPROtein™

The industry standard for RT-QuIC research. Numerous labs use MNPROtein™, allowing for cross-lab comparison of RT-QuIC performance and results from biological and ecological samples like never before.

Using MNPROtein™ for your research? Consider this statement for your methods section, "The RT-QuIC reaction solution was prepared using commercially available truncated prion protein AA-90–231 Syrian hamster substrate (0.1 mg/mL, MNPROtein, Priogen Corp., St. Paul, MN)."

2026

2025

2024

  • Evaluating diagnostic efficacy of pooled samples for CWD testing and surveillance. Pathogens
  • Evaluation of RT-QuIC diagnostic performance for CWD detection using elk (Cervus canadensis) ear punches. Journal of Wildlife Diseases
  • Rapid and sensitive determination of residual prion infectivity from prion-decontaminated surfaces. American Society for Microbiology
  • Rapid on-site amplification and visual detection of misfolded proteins via microfluidic quaking-induced conversion (Micro-QuIC). npj Biosensing
  • Validation of a real-time quaking-induced conversion (RT-QuIC) assay protocol to detect chronic wasting disease using rectal mucosa of naturally infected, pre-clinical white-tailed deer (Odocoileus virginianus). Plos One
  • Detection of Chronic Wasting Disease Prions in Prairie Soils from Endemic Regions. Env. Science and Technology
  • Visual detection of misfolded alpha-synuclein and prions via capillary-based quaking-induced conversion assay (Cap-QuIC). npj Biosensing
  • Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site. Prion
  • Expanding CWD disease surveillance options using environmental contamination at deer signposts. Ecological Solutions and Evidence

2023

  • Nanoparticle-enhanced RT-QuIC (Nano-QuIC) diagnostic assay for misfolded proteins. Nano Letters
  • Standardization of data analysis for RT-QuIC-based detection of chronic wasting disease. Pathogens
  • A field-deployable diagnostic assay for the visual detection of misfolded prions. Scientific Reports

2022

  • Sensitive detection of chronic wasting disease prions recovered from environmentally relevant surfaces. Environmental International
  • Assessment of real-time quaking-induced conversion (RT-QuIC) assay, immunohistochemistry and ELISA for detection of chronic wasting disease under field conditions in white-tailed deer: a Bayesian approach. Pathogens
  • Comparison of chronic wasting disease detection methods and procedures: implications for free-ranging white-tailed deer (Odocoileus virginianus) surveillance and management. Journal of Wildlife Diseases

2021

  • RT-QuIC detection of CWD prion seeding activity in white-tailed deer muscle tissues. Scientific Reports